Published finding — does the expert body still believe it?
Among perfusion-imaging-selected stroke patients treated 6-16 hours after last known well, thrombectomy is associated with functional independence (mRS 0-2) in 45% of patients versus 17% with medical therapy alone (P<0.001).
TL;DR · AI-generated
Endovascular thrombectomy for ischemic stroke 6 to 16 hours after a patient was last known to be well plus standard medical therapy resulted in better functional outcomes than standard medical Therapy alone among patients with proximal middle‐cerebral‐artery or internal‐carotid‐arterY occlusion and a region of tissue that was ischeMIC but not yet infarcted.
Author-implied confidence
93%
Status
DRAFT
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Evidence stream
1 event · 1 snapshot
posterior drift
97% → 97% (0pp · 1 point)
Peer-reviewed paper
Apr 18, 2026
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Source publication
Thrombectomy for Stroke at 6 to 16 Hours with Selection by Perfusion Imaging.
· openalex W2787867590 · s2 ebb91cd3
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Endovascular thrombectomy plus standard care in the 6-24 hour window with clinical-infarct mismatch achieves functional independence (mRS 0-2) at 90 days in 49% of patients versus 13% in the standard care group, an adjusted difference of 33 percentage points.
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Endovascular thrombectomy plus standard medical therapy, compared with standard medical therapy alone, produces a favorable shift in 90-day modified Rankin Scale distribution (OR 2.77, P<0.001) in ischemic stroke patients treated 6 to 16 hours after last known well with perfusion-imaging-selected penumbra.
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Endovascular thrombectomy in the 6-16 hour window is associated with a numerically lower 90-day mortality rate (14%) compared with medical therapy alone (26%, P=0.05) without a significant increase in symptomatic intracranial hemorrhage (7% vs. 4%, P=0.75).
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Intraarterial treatment within 6 hours of stroke onset increased the rate of functional independence (mRS 0–2) at 90 days by an absolute 13.5 percentage points (32.6% vs. 19.1%) compared to usual care alone.
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Ninety-day mortality does not differ significantly between thrombectomy and standard care groups (19% vs 18%) in patients with acute stroke treated 6-24 hours after last known well with clinical-infarct mismatch.
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The REVASCAT trial's stated primary conclusion — Thrombectomy up to 8h after stroke onset is superior to medical therapy in selected patients. — replicates in independent cohorts.