Published finding — does the expert body still believe it?
Patients with atherosclerotic cardiovascular disease whose baseline LDL cholesterol is in the lowest quartile (median ~74 mg/dL) still derive cardiovascular benefit from further LDL lowering with evolocumab.
TL;DR · AI-generated
In this trial, inhibition of PCSK9 with evolocumab on a background of statin therapy lowered LDL cholesterol levels to a median of 30 mg per deciliter (0.78 mmol per liter) and reduced the risk of cardiovascular events.
Author-implied confidence
80%
Status
DRAFT
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Evidence stream
1 event · 1 snapshot
posterior drift
91% → 91% (0pp · 1 point)
Peer-reviewed paper
Apr 18, 2026
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Source publication
Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease.
· openalex W2596179513 · s2 993698dd
Semantically related
Nearest claims in the expert-corpus vector space. Ordered by cosine distance — lower is closer.
0.1112
In patients with atherosclerotic cardiovascular disease on statin therapy, evolocumab reduced LDL cholesterol by 59% at 48 weeks, from a median of 92 mg/dL to 30 mg/dL, compared with placebo.
0.1180
The absolute cardiovascular benefit of alirocumab over placebo is greater in post-ACS patients with a baseline LDL cholesterol of 100 mg/dL or higher compared to those with lower baseline LDL levels.
0.1565
Evolocumab significantly reduced the key secondary composite endpoint of cardiovascular death, MI, or stroke (HR 0.80; 95% CI 0.73–0.88) compared with placebo in ASCVD patients receiving background statin therapy.
0.1619
Evolocumab added to statin therapy significantly reduced the composite primary endpoint of cardiovascular death, MI, stroke, unstable angina hospitalization, or coronary revascularization (HR 0.85; 95% CI 0.79–0.92) in ASCVD patients over a median 2.2-year follow-up.
0.1865
The cardiovascular benefit of evolocumab will be shown to persist or increase with longer follow-up beyond the 2.2-year median observed in the FOURIER trial.
0.2004
The cardiovascular benefit of PCSK9 inhibition with alirocumab will be confirmed as a class effect applicable to other PCSK9 inhibitors in post-ACS patients on maximally tolerated statin therapy.