Published finding — does the expert body still believe it?
Dapagliflozin reduces cardiovascular mortality (HR 0.82; 95% CI 0.69–0.98) in patients with HFrEF compared to placebo.
TL;DR · AI-generated
Among patients with heart failure and a reduced ejection fraction, the risk of worsening heart failure or death from cardiovascular causes was lower among those who received dapagliflozin than amongThose who received placebo, regardless of the presence or absence of diabetes.
Author-implied confidence
82%
Status
DRAFT
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Evidence stream
1 event · 1 snapshot
posterior drift
92% → 92% (0pp · 1 point)
Peer-reviewed paper
Apr 18, 2026
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Source publication
Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction.
· openalex W2974260792 · s2 43e5c9ff
Semantically related
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Dapagliflozin reduces the risk of a first worsening heart failure event (HR 0.70; 95% CI 0.59–0.83) in patients with HFrEF compared to placebo.
0.0500
Dapagliflozin 10 mg once daily reduces the composite of worsening heart failure or cardiovascular death (HR 0.74; 95% CI 0.65–0.85) compared to placebo in patients with HFrEF (EF ≤40%), regardless of diabetes status.
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The DAPA-HF trial's stated primary conclusion — Dapagliflozin reduces heart-failure worsening and CV death in HFrEF with or without diabetes. — replicates in independent cohorts.
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Dapagliflozin does not increase the frequency of adverse events related to volume depletion, renal dysfunction, or hypoglycemia compared to placebo in HFrEF patients.
0.0994
The cardiovascular benefit of dapagliflozin in HFrEF patients is independent of the presence or absence of type 2 diabetes, suggesting glucose-independent mechanisms of action.
0.1101
The EMPEROR-Reduced trial's stated primary conclusion — Empagliflozin reduces cardiovascular death or heart-failure hospitalization in HFrEF regardless of diabetes status. — replicates in independent cohorts.