Active replication — ongoing trial, registry, or meta-analysis.
Recent follow-up analyses of KEYNOTE-189 are confirming the original effect size in real-world data.
TL;DR · AI-generated
In patients with previously untreated metastatic nonsquamous NSCLC without EGFR or ALK mutations, the addition of pembrolizumab to standard chemotherapy of pemetrexed and a platinum‐based drug resulted in significantly longer overall survival and progression‐free survival than chemotherapy alone.
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Evidence stream
2 events · 1 snapshot
posterior drift
71% → 71% (0pp · 1 point)
Registry data
Apr 18, 2026
Peer-reviewed paper
Apr 18, 2026
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Source publication
Pembrolizumab plus Chemotherapy in Metastatic Non–Small-Cell Lung Cancer
Leena Gandhi et al. · New England Journal of Medicine · 2018
· openalex W2796582438 · s2 45c4bb78
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