Published finding — does the expert body still believe it?
Alirocumab added to high-intensity statin therapy reduces the composite risk of coronary heart disease death, nonfatal MI, ischemic stroke, or unstable angina hospitalization compared to placebo in patients with recent acute coronary syndrome (HR 0.85; 95% CI 0.78–0.93).
TL;DR · AI-generated
Among patients who had a previous acute coronary syndrome and who were receiving high‐intensity statin therapy, the risk of recurrent ischemic cardiovascular events was lower among those who received alirocumab than amongThose who received placebo.
Author-implied confidence
95%
Status
DRAFT
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Evidence stream
1 event · 1 snapshot
posterior drift
98% → 98% (0pp · 1 point)
Peer-reviewed paper
Apr 18, 2026
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Source publication
Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome.
· openalex W2899997727 · s2 3bd18f4d
Semantically related
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Alirocumab treatment is associated with a numerically lower all-cause mortality rate compared to placebo in post-ACS patients on high-intensity statins (3.5% vs. 4.1%; HR 0.85; 95% CI 0.73–0.98).
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Evolocumab added to statin therapy significantly reduced the composite primary endpoint of cardiovascular death, MI, stroke, unstable angina hospitalization, or coronary revascularization (HR 0.85; 95% CI 0.79–0.92) in ASCVD patients over a median 2.2-year follow-up.
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Evolocumab significantly reduced the key secondary composite endpoint of cardiovascular death, MI, or stroke (HR 0.80; 95% CI 0.73–0.88) compared with placebo in ASCVD patients receiving background statin therapy.
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The absolute cardiovascular benefit of alirocumab over placebo is greater in post-ACS patients with a baseline LDL cholesterol of 100 mg/dL or higher compared to those with lower baseline LDL levels.
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The cardiovascular benefit of PCSK9 inhibition with alirocumab will be confirmed as a class effect applicable to other PCSK9 inhibitors in post-ACS patients on maximally tolerated statin therapy.
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Alirocumab subcutaneous injection every two weeks causes a higher rate of local injection-site reactions compared to placebo in post-ACS patients (3.8% vs. 2.1%).