Published finding — does the expert body still believe it?
The NURTURE (nusinersen) trial's stated primary conclusion — Presymptomatic nusinersen in SMA infants preserves motor function milestones in long-term follow-up. — replicates in independent cohorts.
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Evidence stream
1 event · 0 snapshots
Registry data
Apr 18, 2026
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Source publication
An Open-Label Study to Assess the Efficacy, Safety, Tolerability, and Pharmacokinetics of Multiple Doses of ISIS 396443 Delivered Intrathecally to Subjects With Genetically Diagnosed and Presymptomatic Spinal Muscular Atrophy
Semantically related
Nearest claims in the expert-corpus vector space. Ordered by cosine distance — lower is closer.
0.1077
Recent follow-up analyses of NURTURE (nusinersen) are confirming the original effect size in real-world data.
0.1178
The STR1VE (onasemnogene abeparvovec / Zolgensma) trial's stated primary conclusion — Single-dose IV AAV9-SMN1 gene therapy produces durable motor benefit in SMA type 1 infants. — replicates in independent cohorts.
0.1655
Recent follow-up analyses of STR1VE (onasemnogene abeparvovec / Zolgensma) are confirming the original effect size in real-world data.
0.1835
By 2028, universal newborn SMA screening + early nusinersen (or onasemnogene/risdiplam) will be standard across all US states and most EU countries.
0.1978
By 2028, long-term follow-up will show durability of Zolgensma motor benefit plateau at ≥5 years post-infusion in early-treated cohorts.
0.2374
Recent follow-up analyses of EARLYSTIM are confirming the original effect size in real-world data.