Active replication — ongoing trial, registry, or meta-analysis.
Recent follow-up analyses of EARLYSTIM are confirming the original effect size in real-world data.
TL;DR · AI-generated
Subthalamic stimulation was superior to medical therapy in patients with Parkinson's disease and early motor complications and time with good mobility and no dyskinesia.
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Evidence stream
2 events · 1 snapshot
posterior drift
71% → 71% (0pp · 1 point)
Registry data
Apr 18, 2026
Peer-reviewed paper
Apr 18, 2026
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Source publication
Neurostimulation for Parkinson's Disease with Early Motor Complications
W.M.M. Schuepbach et al. · New England Journal of Medicine · 2013
· openalex W2106956384 · s2 cb543cbd
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