Intraarterial treatment plus usual care improved 90-day modified Rankin Scale scores compared to usual care alone in patients with acute ischemic stroke from proximal anterior circulation occlusion, with an adjusted common odds ratio of 1.67 (95% CI, 1.21–2.30).

Intraarterial treatment within 6 hours of stroke onset increased the rate of functional independence (mRS 0–2) at 90 days by an absolute 13.5 percentage points (32.6% vs. 19.1%) compared to usual care alone.

Intraarterial treatment for acute ischemic stroke does not significantly increase mortality or symptomatic intracerebral hemorrhage rates compared to usual care alone.

Endovascular thrombectomy plus standard care, performed 6 to 24 hours after stroke onset in patients with clinical-infarct mismatch, improves mean utility-weighted modified Rankin Scale score at 90 days compared to standard care alone (5.5 vs 3.4, adjusted difference 2.0 points).

Endovascular thrombectomy plus standard medical therapy, compared with standard medical therapy alone, produces a favorable shift in 90-day modified Rankin Scale distribution (OR 2.77, P<0.001) in ischemic stroke patients treated 6 to 16 hours after last known well with perfusion-imaging-selected penumbra.

The functional benefit of intraarterial treatment is achievable even when the majority of patients (89%) have already received intravenous alteplase prior to endovascular intervention.

Endovascular thrombectomy plus standard care in the 6-24 hour window with clinical-infarct mismatch achieves functional independence (mRS 0-2) at 90 days in 49% of patients versus 13% in the standard care group, an adjusted difference of 33 percentage points.