Published finding — does the expert body still believe it?
The DEFUSE-3 trial's stated primary conclusion — Imaging-selected patients benefit from thrombectomy 6–16h after last-known-well. — replicates in independent cohorts.
TL;DR · AI-generated
Endovascular thrombectomy for ischemic stroke 6 to 16 hours after a patient was last known to be well plus standard medical therapy resulted in better functional outcomes than standard medical Therapy alone among patients with proximal middle‐cerebral‐artery or internal‐carotid‐arterY occlusion and a region of tissue that was ischeMIC but not yet infarcted.
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Evidence stream
2 events · 1 snapshot
posterior drift
71% → 71% (0pp · 1 point)
Registry data
Apr 18, 2026
Peer-reviewed paper
Apr 18, 2026
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Source publication
Thrombectomy for Stroke at 6 to 16 Hours with Selection by Perfusion Imaging
Gregory W. Albers et al. · New England Journal of Medicine · 2018
· openalex W2787867590 · s2 ebb91cd3
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Among perfusion-imaging-selected stroke patients treated 6-16 hours after last known well, thrombectomy is associated with functional independence (mRS 0-2) in 45% of patients versus 17% with medical therapy alone (P<0.001).