Forecast horizon — calibration-scored at resolution.
The benefit of late-window thrombectomy identified in DEFUSE 3 will generalize to stroke patients with posterior circulation (basilar artery) occlusion selected by perfusion imaging in the 6-16 hour window.
TL;DR · AI-generated
Endovascular thrombectomy for ischemic stroke 6 to 16 hours after a patient was last known to be well plus standard medical therapy resulted in better functional outcomes than standard medical Therapy alone among patients with proximal middle‐cerebral‐artery or internal‐carotid‐arterY occlusion and a region of tissue that was ischeMIC but not yet infarcted.
Author-implied confidence
48%
Current probability
Status
DRAFT
Your probability this resolves TRUE
0% (impossible)
50%
100% (certain)
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Evidence stream
1 event · 1 snapshot
posterior drift
70% → 70% (0pp · 1 point)
Peer-reviewed paper
Apr 18, 2026
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Source publication
Thrombectomy for Stroke at 6 to 16 Hours with Selection by Perfusion Imaging.
· openalex W2787867590 · s2 ebb91cd3
Semantically related
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The DEFUSE-3 trial's stated primary conclusion — Imaging-selected patients benefit from thrombectomy 6–16h after last-known-well. — replicates in independent cohorts.
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The DAWN trial's stated primary conclusion — Mechanical thrombectomy benefits selected large-vessel-occlusion stroke patients in the 6–24h window. — replicates in independent cohorts.
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A perfusion-imaging mismatch ratio of ≥1.8 with infarct volume <70 ml reliably identifies late-window stroke patients who benefit from thrombectomy, supporting its use as a patient-selection criterion beyond 6 hours.
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The REVASCAT trial's stated primary conclusion — Thrombectomy up to 8h after stroke onset is superior to medical therapy in selected patients. — replicates in independent cohorts.
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By 2028, late-window thrombectomy (6–24h) will be explicitly endorsed by AHA/ASA guidelines as standard-of-care in qualifying LVO patients across at least 80% of US comprehensive stroke centers.
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The MR CLEAN trial's stated primary conclusion — Endovascular thrombectomy within 6h improves functional outcome in proximal anterior circulation stroke. — replicates in independent cohorts.