Active replication — ongoing trial, registry, or meta-analysis.
The clinical-infarct mismatch paradigm, stratified by age (<80 vs ≥80 years), successfully identifies patients with intracranial ICA or proximal MCA occlusion who benefit from late-window thrombectomy.
Author-implied confidence
75%
Live consensus
Status
DRAFT
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Evidence stream
1 event · 1 snapshot
posterior drift
88% → 88% (0pp · 1 point)
Peer-reviewed paper
Apr 18, 2026
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Source publication
Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct.
· openalex W2767776410 · s2 e3b1d93d
Semantically related
Nearest claims in the expert-corpus vector space. Ordered by cosine distance — lower is closer.
0.0953
A perfusion-imaging mismatch ratio of ≥1.8 with infarct volume <70 ml reliably identifies late-window stroke patients who benefit from thrombectomy, supporting its use as a patient-selection criterion beyond 6 hours.
0.1579
The DAWN trial's stated primary conclusion — Mechanical thrombectomy benefits selected large-vessel-occlusion stroke patients in the 6–24h window. — replicates in independent cohorts.
0.1625
The REVASCAT trial's stated primary conclusion — Thrombectomy up to 8h after stroke onset is superior to medical therapy in selected patients. — replicates in independent cohorts.
0.1643
The DEFUSE-3 trial's stated primary conclusion — Imaging-selected patients benefit from thrombectomy 6–16h after last-known-well. — replicates in independent cohorts.
0.1765
The benefit of late-window thrombectomy identified in DEFUSE 3 will generalize to stroke patients with posterior circulation (basilar artery) occlusion selected by perfusion imaging in the 6-16 hour window.
0.1821
Ninety-day mortality does not differ significantly between thrombectomy and standard care groups (19% vs 18%) in patients with acute stroke treated 6-24 hours after last known well with clinical-infarct mismatch.